Manic-Depressive Illness and Creativity; Mysteries of the Mind; Scientific American Presents; by Jamison; 6 Page(s)

"Men have called me mad," wrote Edgar Allan Poe, "but the question is not yet settled, whether madness is or is not the loftiest intelligence--whether much that is glorious--whether all that is profound--does not spring from disease of thought--from moods of mind exalted at the expense of the general intellect."

Many people have long shared Poe's suspicion that genius and insanity are entwined. Indeed, history holds countless examples of "that fine madness." Scores of influential 18th- and 19th-century poets, notably William Blake, Lord Byron and Alfred, Lord Tennyson, wrote about the extreme mood swings they endured. Modern American poets John Berryman, Randall Jarrell, Robert Lowell, Sylvia Plath, Theodore Roethke, Delmore Schwartz and Anne Sexton were all hospitalized for either mania or depression during their lives. And many painters and composers, among them Vincent van Gogh, Georgia O'Keeffe, Charles Mingus and Robert Schumann, have been similarly afflicted.